So far, only two ECS receptors are known:
- The CB1 receptor, which is localised primarily in the brain (hippocampus, cerebellum) and also in the intestine.
- CB2 receptors, which in contract are found primarily in the immune system as well as in osteoblasts and osteoclasts.
Despite the fact that so far only two receptors of the system are known, the existence of others is suspected.
These receptors interact with cannabinoids (endogenous and exogenous). The receptors could be thought of as a docking station or a lock, with the cannabinoids such as CBD or THC being the respective keys. This collaboration sends signals that ultimately trigger certain effects in the body.
For example, it has already been found that the correct activation of the CB1 receptors can promote an antidepressant effect.
Also the results of studies show that CB1 receptors may play a role in erasing negative memories, and therefore the endocannabinoid system may play an important role in anxiety disorders.
With the help of these receptors, the ECS can also regulate the following:
- Immune function
- Sleep-wake rhythm
- Reproduction / fertility
- Anxiety / panic attacks
But, as with most things in nature and the human body, it is also important that the system of different receptors remains in balance. This is because a surplus, just like a deficiency, can lead to disturbances and, in the worst case, to illnesses.
If one consumes THC, which interacts especially with the CB1 receptors, a worst case scenario would be that it could lead to psychosis. However, according to a WHO report, CBD does not cause any health complaints.